Depression is one of the most common mental illnesses throughout the world. The rate of depression cases has skyrocketed in recent years due to the COVID-19 pandemic and the enforced social isolation conditions. Studies published by Brown University found that depression cases more than tripled during the pandemic.

Doctors can prescribe antidepressants to help treat symptoms of depression. However, people who prefer more organic and non-prescription forms of treatment are relying on CBD oil to help treat their depression symptoms. CBD has been known to calm the mind and help coax people into relaxed states, helping reduce the harmful effects of the more common depression symptoms.

However, is it possible to mix the two forms of treatments? Can you take CBD and antidepressants safely without risking your overall health? Let’s look into those questions and provide some helpful answers.

Is CBD good for depression?

People have used CBD to treat their own symptoms of depression, but there is a body of research to support CBD therapy as optimal for people living with depression. According to one of those studies, CBD can help boost levels of serotonin within the brain. Serotonin directly influences your mood and well-being, including overall feelings of happiness. Having therapy that can help maintain serotonin within the body is one of the best ways to treat depression.

CBD is also known to reduce levels of stress, improve responses to anxiety, and even help support you through a restful night of sleep. CBD’s ability to relax both the body and the mind helps support the serotonin levels that already circulate throughout your brain, which can help reduce symptoms of depression and improve overall happiness.

Can you take CBD and antidepressants

Can you take CBD and antidepressants? As of the time of this writing, there is still much research that needs to be done surrounding the benefits of CBD. While preliminary studies have shown that people can benefit from taking regular doses of CBD, those trials have not been proven medically conclusive yet.

However, one study that was conducted by a team of researchers at Harvard Medical School did look into whether you can safely take CBD and antidepressants together. Their findings show that CBD can alter the effects of antidepressants and other medications, potentially negating the purpose of using those prescribed medications in the first place.

What could happen if you take CBD and antidepressants together

CBD and antidepressants, taken together, could increase feelings of drowsiness and fatigue. For safety purposes, it’s best to speak to your primary doctor about your plans to take CBD and antidepressants to ensure you are supporting your own health by combining the two.

While not prescribed antidepressant medication, some people do use alcohol to alter their moods as a coping mechanism. The Harvard study recommends that people avoid consuming large amounts of alcohol while taking CBD oil as it can cause the same heavy drowsiness that can occur when mixed with other antidepressants.

If you are currently on prescribed medication, it would be wise to speak with your primary doctor about your plans to start taking CBD and antidepressants. Your doctor will know if CBD will negate the effects of your medication and vice versa. He or she may also offer a recommended dosage of CBD oil to take as part of your organic therapy.

What drugs should not be taken with CBD?

In addition to antidepressants, the study also lists other medications that could be affected if consumed alongside CBD. Those medications include:

  • Opioids
  • Benzodiazepines
  • Antipsychotics
  • Antihistamines

In terms of specific examples of what drugs should not be taken with CBD oil, the Harvard study recommends avoiding mixing any cannabinoids with the following examples of medications. Due to how CBD interacts with the body’s endocannabinoid system; attaching itself to key receptors in the body to regulate signals between the brain and various nerve cells, the effects of CBD could negate the effects of the following medications.


Warfarin is a blood thinner often recommended to treat blood clots that may form in your body. It’s also known as an anticoagulant for its ability to keep blood pumping effectively through your veins without resulting in clotting and other complications.


Amiodarone is used to treat heart murmurs that pose serious and often life threatening dangers to the patients. It helps to relax overactive heart muscles that become too stimulated.


Levothyroxine is a thyroid medication. Similar to how CBD can substitute for endocannabinoids in that bodily system, levothyroxine substitutes for a deficient number of hormones that may be produced by your thyroid to regulate the body’s energy levels.